So according to the very short description [below] of the first show...any predictions?
The doctors of Seattle Grace help Izzie cope with the loss of her fianci, Denny, and her decision to quit the internship program. Meredith must decide what the future holds after her hospital liaison with Derek. The Chief is confronted by his wife, Adele, after spending the night in his office, and George seeks relationship advice from a surprising source, on the season premiere of Grey's Anatomy.
I think that Geroge is going to ask Meredith for advice...the only suprising source I can think of.