Hoss
1
not every pill you take goes into your system. it has a lot to do with bioavailability and whether it is completely disassiciated in your liver.. the ba of pyruvate is about 50%, unless injected.
Two human studies evaluated pyruvate's role as a fat and weight reductant (11, 12). In both investigations, treatment subjects lost more fat and weight than the control group, but only one found these percentages (11). Considerably smaller changes (23% greater fat loss and 16% greater weight loss) were noted in the other study (12). This claim is particularly misleading to consumers since these "significant" percentages actually amount to only a few pounds. The widely popular 48% translates to a mere 1.3 kg or 2.86 lbs and 37% is really 1.6 kg or 3.52 lbs--hardly the significant losses dieters have come to expect. Furthermore, these percentages have no practical relevance outside the context of a research article (How does a consumer quantify 48 and 37%?). A formal research environment differs from the real world in that the latter presents many confounding variables, so results (or lack thereof) may be attributable to factors unrelated to pyruvate supplementation.
The experimental protocol was extremely exclusive. All subjects were: 1) morbidly obese women; 2) housed in a metabolic ward for 21 days; 3) confined to bed except for walking to the restroom and kitchen; and 4) restricted to a 500 to 1,000 kcal liquid diet. As such, the results of these studies are specific to these criteria and cannot be reliably generalized to the population at large.
Two human studies evaluated pyruvate's role as a fat and weight reductant (11, 12). In both investigations, treatment subjects lost more fat and weight than the control group, but only one found these percentages (11). Considerably smaller changes (23% greater fat loss and 16% greater weight loss) were noted in the other study (12). This claim is particularly misleading to consumers since these "significant" percentages actually amount to only a few pounds. The widely popular 48% translates to a mere 1.3 kg or 2.86 lbs and 37% is really 1.6 kg or 3.52 lbs--hardly the significant losses dieters have come to expect. Furthermore, these percentages have no practical relevance outside the context of a research article (How does a consumer quantify 48 and 37%?). A formal research environment differs from the real world in that the latter presents many confounding variables, so results (or lack thereof) may be attributable to factors unrelated to pyruvate supplementation.
The experimental protocol was extremely exclusive. All subjects were: 1) morbidly obese women; 2) housed in a metabolic ward for 21 days; 3) confined to bed except for walking to the restroom and kitchen; and 4) restricted to a 500 to 1,000 kcal liquid diet. As such, the results of these studies are specific to these criteria and cannot be reliably generalized to the population at large.