Well, of course, it depends. I'm not quite sure I fully understand your question. Do you mean replace chicken with ground beef in a particular recipe? Or are you just a big chicken eater and you want to eat more beef instead of chicken, for whatever reason? In any case, sure, you can eat ground beef. It's a better source of iron than chicken. Of course, it's a great source of protein, but then again, so it chicken. Regardless of whether you are eating chicken or beef, I recommend the most natural stuff you can get. Not necessarily certified organic, although that would be good. In any case, try to avoid meat/poultry with antibiotics and hormones. Ground beef is generally fattier than chicken, depending on what you're buying and how you are cooking it, but you can buy lean ground beef and minimize your fat. Both beef and chicken fat is mostly unhealthy saturated fat, so try to get the leanest product you can, whether you're buying beef or chicken. If you are attempting to increase muscle mass, it's not as important to minimize your saturated fat intake as compared to someone looking to lose weight, but all people should limit their saturated fat intake. When you cook ground beef on a grill at high temperatures, it can form cancer-causing compounds. That's not to say you shouldn't ever eat meat off of the grill, but you might want to limit how often you do it. Of course, you also need to make sure ground beef is cooked well enough to prevent foodborne illness.