It does not matter when you take it. It should be a part of a diet of 1-2 grams of protien per pound of body weight and an excess of calories above your maintenace level, including adeqaute good fats, healthy carbs, vitamins and minerals, coupled with a good resistance exercise routine to allow you to increase lean body mass. Read the stickies on this site in the weightlifting and nutrition sections for more info.