I am assuming you mean LEGAL pills right, since there are many not legal one that work well. And I don't mean speed or any hard drug.
As far as losing the natural way ....THERE IS NO SUCH THING AS SPOT REDUCTION !!!!!!!! You can't lose weight in any certain area no matter how well you think you know your body. It decides for you when and where you will lose. You just need some for of thermogenic pill like hydroxicut or ripped/diet fuel. These are loaded with herbal caffene which will speed you up a bit. BUT the main thing is you need to change your diet!! You need to eat 6 times a day. 3 regular meals and 3 small meals. Eat every 2-3 hours. This will set your body up for fat loss since it detects regular caloric intake. Then do cardio every day if possible. Dont do the same thing every day, run/swim/bike etc....