That is very interesting and helpful for me Red Panda. I recently had issues with both legs cramping up all over on very short distances running. I waited a few weeks before finally going to the doctor and my legs were actually starting to feel better, but my liver muscle enzymes were over double what they were supposed to be, and I assume they were a lot higher than that when they were worse. All the issues I had were symptoms of high muscle enzymes. At the time I was taking codeine for a root canal, ibuprofin, creatine, plus I was doing both weights and cardio. I think it was just too much stress on my liver. I continued to have muscle spasms in my calves, but they weren't really an issue I found that the muscle spasms gradually went away when I stopped taking creatine. I think it is mostly related to pushing the muscles, but creatine seemed to influence it some. I plan to go back on creatine in about a month and see how it goes.